Formaldehyde is often applied in the industrial production of different products, such as textiles, insulation materials, or cosmetics, due to its preservative and disinfectant properties. However, formaldehyde is classified by the International Agency for Research on Cancer as carcinogenic, and there are numerous studies about the pernicious health effects that frequent exposure to formaldehyde can pose to human health. In the cosmetic industry, compounds called formaldehyde releasers are added during production, with the intent of releasing small amounts of formaldehyde over time. Although there are many methods available for the determination of formaldehyde, they are usually not suitable for the determination of free formaldehyde in cosmetics with formaldehyde releasers in their composition, as they can promote the accelerated release of formaldehyde. In this work, the gas-diffusion microextraction (GDME) technique was used for the extraction of formaldehyde from cosmetic and personal hygiene products. Acetylacetone was used as the derivatization reagent which was later used for the spectrophotometric determination of formaldehyde. The developed methodology exhibits limits of detection (1.98 mg kg⁻¹) and quantification (6.60 mg kg⁻¹) perfectly adequate for the determination of formaldehyde in these samples. Formaldehyde values between 6.9 ± 0.3 and 365 ± 15 mg kg⁻¹ were found in samples containing the formaldehyde releasers DMDM hydantoin, Diazolidinyl urea, and Bronopol. Furthermore, mass spectrometry studies were performed in order to unbiasedly ensure the presence of formaldehyde in every extract. GDME proved to be an economical, simple, and robust alternative for the extraction of free formaldehyde in personal hygiene and cosmetic samples.

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由于甲醛的防腐和消毒特性，经常将其用于工业生产各种产品，例如纺织品，绝缘材料或化妆品。但是，国际癌症研究机构将甲醛归类为致癌物质，并且有许多关于频繁暴露于甲醛会危害人体健康的有害健康影响的研究。在化妆品工业中，在生产过程中会添加称为甲醛释放剂的化合物，目的是随着时间的流逝释放少量甲醛。尽管有许多方法可用于测定甲醛，但是它们通常不适合测定组成中含有甲醛释放剂的化妆品中的游离甲醛，因为它们可以促进甲醛的加速释放。在这项工作中，气体扩散微萃取（GDME）技术用于从化妆品和个人卫生产品中提取甲醛。乙酰丙酮用作衍生试剂，随后用于分光光度法测定甲醛。发达的方法显示出检测限（1.98 mg kg^-1）和定量分析（6.60 mg kg ^-1）非常适合测定这些样品中的甲醛。在含有甲醛释放剂DMDM乙内酰脲，重氮烷基脲和Bronopol的样品中发现甲醛值介于6.9±0.3和365±15 mg kg ^-1之间。此外，进行质谱研究以公正地确保每种提取物中都存在甲醛。事实证明，GDME是一种用于提取个人卫生和化妆品样本中游离甲醛的经济，简单和耐用的替代方法。

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