Facile Chemoselective Modification of Thio-Ethers Generates Chiral Center-Induced Helical Peptides,Bioconjugate Chemistry

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Facile Chemoselective Modification of Thio-Ethers Generates Chiral Center-Induced Helical Peptides
Bioconjugate Chemistry ( IF 4.0 ) Pub Date : 2018-09-07 00:00:00 , DOI: 10.1021/acs.bioconjchem.8b00624
Zhanfeng Hou ₁ , Chengjie Sun ₁ , Hao Geng ₁ , Kuan Hu ₁ , Mingsheng Xie ₁ , Yue Ma ₁ , Fan Jiang ₁ , Feng Yin ₁ , Zigang Li ₁

Affiliation

A precisely positioned sulfimide chiral center on-tether of a thio-ether tethered peptide determines the peptide secondary structure by chemoselective oxaziridine modification. This method provides a facile way to tune peptides’ secondary structures and biophysical properties.

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