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Facile Chemoselective Modification of Thio-Ethers Generates Chiral Center-Induced Helical Peptides
Bioconjugate Chemistry ( IF 4.0 ) Pub Date : 2018-09-07 00:00:00 , DOI: 10.1021/acs.bioconjchem.8b00624
Zhanfeng Hou 1 , Chengjie Sun 1 , Hao Geng 1 , Kuan Hu 1 , Mingsheng Xie 1 , Yue Ma 1 , Fan Jiang 1 , Feng Yin 1 , Zigang Li 1
Affiliation  

A precisely positioned sulfimide chiral center on-tether of a thio-ether tethered peptide determines the peptide secondary structure by chemoselective oxaziridine modification. This method provides a facile way to tune peptides’ secondary structures and biophysical properties.

中文翻译:

硫醚的简便化学选择性修饰产生手性中心诱导的螺旋肽。

硫醚系留肽的系链上精确定位的磺酰亚胺手性中心通过化学选择性的恶唑烷修饰修饰确定肽的二级结构。该方法提供了一种简便的方法来调节肽的二级结构和生物物理特性。
更新日期:2018-09-07
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