Abstract Intrinsically conducting polymers (ICPs) such as poly(3,4-ethylenedioxythiophene) (PEDOT) have attracted significant interest for the development of flexible light-emitting diodes, electrochromic devices and solar cells, as well as for a variety of biosensing and regenerative medicine applications. Herein, we disclose the use of water-soluble self-folded metal-containing single-chain nanoparticles (SCNPs) as robust enzyme-mimic nanoreactors for the synthesis of ICPs via step-growth polymerization. As a proof of concept, we report the first enzyme-mimetic synthesis of PEDOT at room temperature (r.t.) via oxidative polymerization using self-folded iron-containing SCNPs as efficient artificial pseudo-enzymes. Remarkably, this work paves the way to the synthesis of other types of ICPs (e.g., polyaniline, polypyrrole) using water-soluble metal-containing SCNPs as robust enzyme-mimic nanoreactors operating at r.t., and expands the use of SCNPs as bioinspired catalysts from chain-growth polymerization (i.e., ring-opening polymerization and living radical polymerization) to step-growth polymerization (i.e., polycondensation via oxidative polymerization).

中文翻译：

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自折叠含铁单链纳米粒子酶法合成 PEDOT

摘要 本征导电聚合物 (ICPs) 如聚 (3,4-乙撑二氧噻吩) (PEDOT) 在柔性发光二极管、电致变色器件和太阳能电池的开发以及各种生物传感和再生方面引起了极大的兴趣。医学应用。在此，我们公开了使用水溶性自折叠含金属单链纳米粒子 (SCNP) 作为稳健的酶模拟纳米反应器，通过逐步生长聚合合成 ICP。作为概念的证明，我们报告了使用自折叠含铁 SCNP 作为有效的人工假酶通过氧化聚合在室温 (rt) 下首次酶模拟合成 PEDOT。值得注意的是，这项工作为合成其他类型的 ICP（例如聚苯胺、