Metallodrugs have become an integral part of modern medicinal chemistry with platinum drugs as anti-cancer agents being well-known examples. The historically interesting compound Zeise's salt, potassium trichlorido(ethene)platinate(II) has scarcely been investigated in this context yet. This study is geared towards shedding light on the biological reactivity of this platinum complex. Mass Spectrometry tools were used to obtain a deeper understanding of its interactions with biomolecules on the molecular level. Angiotensin I and Ubiquitin were chosen as model systems. Comparison to Cisplatin show that Zeise's salt is more reactive towards nucleophilic sites in proteins. Our data indicate that the ethylene ligand remains on the platinum when coordinated to a nitrogen donor in the biomolecule and therefore offers a linkage for the introduction of further functionality. When attached to sulfur donors in the biomolecule, platinum(II) provides a site for the formation of crosslinks and loops in the biomolecules by losing all four of its initial ligands.

金属药物已经成为现代药物化学中不可或缺的一部分，铂类药物作为抗癌剂是众所周知的例子。在这种情况下，几乎没有研究过具有历史意义的化合物Zeise的盐，即三氯二（乙烯）铂酸钾（II）。这项研究旨在揭示这种铂络合物的生物反应性。使用质谱分析工具可以更深入地了解其与生物分子在分子水平上的相互作用。选择血管紧张素I和泛素作为模型系统。与顺铂的比较表明，Zeise盐对蛋白质中的亲核位点更具反应性。我们的数据表明，当与生物分子中的氮供体配位时，乙烯配体仍保留在铂上，因此为引入其他功能性提供了联系。当与生物分子中的硫供体连接时，铂（II）通过失去其所有四个初始配体，提供了在生物分子中形成交联和环的位点。