MALDI-LID-ToF/ToF analysis of statistical and diblock polyacrylate copolymers†,Polymer Chemistry

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MALDI-LID-ToF/ToF analysis of statistical and diblock polyacrylate copolymers†
Polymer Chemistry ( IF 4.1 ) Pub Date : 2018-09-07 00:00:00 , DOI: 10.1039/c8py00928g
James S. Town _{1,

2,

3,

4} , Glen R. Jones _{1,

2,

3,

4} , David M. Haddleton _{1,

2,

3,

4}

Affiliation

We report the use of MALDI-LID-ToF/ToF utilising the laser induced dissociation (LID) fragmentation technique, which has been almost exclusively applied to protein/peptide analysis to date. MALDI-LID-ToF/ToF is used as a powerful tool to give information of monomer distributions in synthetic co-poly(acrylates). Analysis of a range of poly(acrylate) homopolymers by LID have found slight improvement over CID, with less rearrangements in the poly(butyl acrylate) fragmentation and more backbone cleavages. Analysis of both block and statistical copolymers, when compared to homopolymer analogues, yield markedly different spectra which can be correlated to give some monomer sequence information, thus achieving a wealth of structural information from two samples which would otherwise be identical by single stage MALDI-ToF analysis. The determination of fragmentation pathways of polymers with varying end group lability and monomer structure has allowed for high-resolution microstructural determination at the block boundary, showing even small amounts of mixing at the block boundary.

中文翻译：

统计和二嵌段聚丙烯酸酯共聚物的MALDI-LID-ToF / ToF分析†

我们报告了利用MALDI-LID-ToF / ToF利用激光诱导解离（LID）片段化技术，迄今为止该技术几乎仅用于蛋白质/肽分析。MALDI-LID-ToF / ToF是一种功能强大的工具，可提供合成共聚（丙烯酸酯）中单体分布的信息。通过LID对一系列聚丙烯酸酯均聚物的分析发现，与CID相比有轻微改进，聚丙烯酸丁酯片段化的重排较少，主链裂解程度更高。与均聚物类似物相比，对嵌段共聚物和统计共聚物的分析均产生明显不同的光谱，可以将它们关联起来以提供一些单体序列信息，从而从两个样品中获得大量的结构信息，否则它们与单阶段MALDI-ToF相同分析。

更新日期：2018-09-07

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