Many biologically active water-insoluble drug molecules have limited clinical application because of strong hydrophobicity. Recently triblock copolymers have attracted enormous interest as potential drug carriers. For the purpose of delivering the 5-(1-(bromohexa-1,3,5-triyn-1-yl)-3a,4,5,6,7,7a-hexahydro-1H-4,7-methanoindazol-3-yl)-3-methyl-1-phenyl-1H-pyrazole-4-carbonitrile (PYZ) molecule, triblock copolymers are used. In order to understand the delivery of this water-insoluble probe through triblock copolymers (TBP), the solvent-dependent fluorescence properties of this compound have been examined in different homogeneous solvents. Besides the experimental work, theoretical studies have also been conducted to explain actual orientation of atoms in PYZ through optimized structures to support the experimental findings. Moreover, the three TBP polymers P-123 (PEO19 PPO69 PEO19 ), F-127 (PEO100 PPO65PEO100 ) and L-64 (PEO13 PPO30 PEO13 ) have been treated here as potential carriers that encapsulate a pyrazoline derivative. The consequence of spatial captivity on the emission properties was systematically visualized by means of steady-state and time-resolved fluorescence spectroscopy. From DLS measurements the size variation with the polydispersity index of TBP in the presence and absence of PYZ in different triblock copolymers was also monitored. Furthermore these measurements have been supported by TEM imaging also.

中文翻译：

---

通过溶剂变色行为破译嵌段共聚物作为吡唑啉衍生物的载体：光谱学和理论探索。

由于强疏水性，许多具有生物活性的水不溶性药物分子具有有限的临床应用。最近，三嵌段共聚物作为潜在的药物载体引起了极大的兴趣。为了递送5-（1-（溴六-1,3,5-三炔-1-基）-3a，4,5,6,7,7a-六氢-1H-4,7-甲基吲哚-3 -PyZ）分子是使用三嵌段共聚物的（-基）-3-甲基-1-苯基-1H-吡唑-4-甲腈（PYZ）分子。为了了解这种水溶性探针通过三嵌段共聚物（TBP）的传递，已在不同的均相溶剂中检查了该化合物的溶剂依赖性荧光性质。除实验工作外，还进行了理论研究，以通过优化结构来支持PYZ中原子的实际取向，以支持实验结果。而且，在此，将三种TBP聚合物P-123（PEO19 PPO69 PEO19），F-127（PEO100 PPO65PEO100）和L-64（PEO13 PPO30 PEO13）视为潜在的载有吡唑啉衍生物的载体。借助稳态和时间分辨荧光光谱系统地观察了空间俘获对发射性质的影响。通过DLS测量，还监测了在不同三嵌段共聚物中存在和不存在PYZ的情况下，TBP的多分散性指数的大小变化。此外，这些测量也得到了TEM成像的支持。借助稳态和时间分辨荧光光谱系统地观察了空间俘获对发射性质的影响。通过DLS测量，还监测了在不同三嵌段共聚物中存在和不存在PYZ的情况下，TBP的多分散性指数的大小变化。此外，这些测量也得到了TEM成像的支持。借助稳态和时间分辨荧光光谱系统地观察了空间俘获对发射性质的影响。通过DLS测量，还监测了在不同三嵌段共聚物中存在和不存在PYZ的情况下，TBP的多分散性指数的大小变化。此外，这些测量也得到了TEM成像的支持。