Polyurethane (PU) nanoparticles are potential drug carriers. We aimed to study the in vitro and in vivo efficacy of biodegradable PU nanoparticles loaded with fenofibrate (FNB-PU) on nonalcoholic fatty liver disease (NAFLD). FNB-PU was prepared by a green process, and its preventive effects on NAFLD were investigated on HepG2 cells and mice. FNB-PU showed sustained in vitro FNB release profile. Compared to FNB crude drug, FNB-PU significantly decreased triglyceride content in HepG2 cells incubated with oleic acid and in livers of mice with NAFLD induced by a methionine choline deficient diet, and increased plasma FNB concentration of the mice. FNB-PU increased absorption of FNB and therefore enhanced the inhibitory effects of FNB on NAFLD.

中文翻译：

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聚氨酯纳米粒非诺贝特对小鼠非酒精性脂肪肝具有抑制作用

聚氨酯（PU）纳米颗粒是潜在的药物载体。我们旨在研究载有非诺贝特（FNB-PU）的可生物降解PU纳米颗粒对非酒精性脂肪肝疾病（NAFLD）的体外和体内功效。通过绿色工艺制备FNB-PU，并研究其对HepG2细胞和小鼠的NAFLD预防作用。FNB-PU显示出持续的体外FNB释放曲线。与FNB原料药相比，FNB-PU显着降低了由油酸孵育的HepG2细胞和甲硫氨酸胆碱缺乏饮食诱导的NAFLD小鼠肝脏中甘油三酸酯的含量，并增加了小鼠血浆FNB的浓度。FNB-PU增加了FNB的吸收，因此增强了FNB对NAFLD的抑制作用。