Solid-state chiral resolution mediated by stoichiometry: crystallizing etiracetam with ZnCl2†,Chemical Communications

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Solid-state chiral resolution mediated by stoichiometry: crystallizing etiracetam with ZnCl2†
Chemical Communications ( IF 4.3 ) Pub Date : 2018-09-06 00:00:00 , DOI: 10.1039/c8cc06199h
Oleksii Shemchuk _{1,

2,

3,

4,

5} , Lixing Song _{6,

7,

8,

9} , Koen Robeyns _{6,

7,

8,

9} , Dario Braga _{1,

2,

3,

4,

5} , Fabrizia Grepioni _{1,

2,

3,

4,

5} , Tom Leyssens _{6,

7,

8,

9}

Affiliation

Chiral resolution of racemic etiracetam was achieved via co-crystallization with ZnCl₂. Depending on the amount of ZnCl₂ either a stable racemic compound or a stable conglomerate can be obtained. Excess ZnCl₂ triggers the quantitative conversion of the racemate into the conglomerate solid; this unprecedented behaviour was investigated through a racetam/ZnCl₂/solvent phase diagram.

中文翻译：

化学计量学介导的固态手性拆分：用ZnCl ₂†结晶乙拉西坦

外消旋乙拉西坦的手性拆分是通过与ZnCl ₂共结晶实现的。根据ZnCl ₂的量，可以得到稳定的外消旋化合物或稳定的团聚体。过量的ZnCl ₂引发外消旋物定量转化为团状固体。通过消旋体/ ZnCl ₂ /溶剂相图研究了这种空前的行为。

更新日期：2018-09-06

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