Schizophrenia and Alzheimer’s disease impacts on various sensory processings are extensively reviewed in the present publication. This article describes aspects of a research project whose aim is to delineate the neurobiology that may underlie Social Withdrawal in Alzheimer’s disease, Schizophrenia and Major Depression. This is a European-funded IMI 2 project, identified as PRISM (Psychiatric Ratings using Intermediate Stratified Markers). This paper focuses specifically on the selected electrophysiological paradigms chosen based on a comprehensive review of all relevant literature and practical constraints. The choice of the electrophysiological biomarkers were fundamentality based their metrics and capacity to discriminate between populations. The selected electrophysiological paradigms are resting state EEG, auditory mismatch negativity, auditory and visual based oddball paradigms, facial emotion processing ERP’s and auditory steady-state response. The primary objective is to study the effect of social withdrawal on various biomarkers and endophenotypes found altered in the target populations. This has never been studied in relationship to social withdrawal, an important component of CNS diseases.

精神分裂症和阿尔茨海默氏病对各种感觉过程的影响在本出版物中进行了广泛的综述。本文介绍了一个研究项目的各个方面，其目的是描述可能是阿尔茨海默氏病，精神分裂症和严重抑郁症社交退缩的基础的神经生物学。这是由欧洲资助的IMI 2项目，被确定为PRISM（使用中间分层标记的精神病学评分）。本文重点介绍了在对所有相关文献和实际限制条件进行全面审查的基础上选择的所选电生理学范式。电生理生物标志物的选择是基于其量度和区分人群的能力的基本性。选择的电生理范式是静止状态EEG，听觉失配阴性，基于听觉和视觉的奇异球范例，面部表情处理ERP和听觉稳态响应。主要目标是研究社交退缩对目标人群中发现的各种生物标志物和内表型的影响。关于中枢神经系统疾病的重要组成部分社会退缩的研究从未进行过研究。