In the present study, crosslinking of agar using diisocyanate (DI) was demonstrated to limit the high water absorption property of agar. In addition, the efficacy of aromatic diisocyanate, DDI (4, 4 diphenyl diisocyanate) and aliphatic diisocyanate, HDI (1, 6 hexamethylene diisocyanate) on crosslinked agar properties was compared. The water uptake was successfully reduced by crosslinking and its minimum values observed for DDI and HDI crosslinked agar was 33.6% and 43.6%, respectively in comparison to agar (206%). The maximum tensile strength was observed for DDI crosslinked agar (45.3 MPa) which was higher than HDI crosslinked agar (30.6 MPa) and agar (31.7 MPa). The aromatic diisocyanates crosslinked agar showed better thermal resistance at higher temperature. It was observed that aromatic diisocyanate crosslinked agar more effectively than the aliphatic diisocyanate due to the higher reactivity. The crosslinked agar samples were hemocompatible and show non-toxic nature for cell proliferation.

在本研究中，已证明使用二异氰酸酯（DI）进行琼脂交联会限制琼脂的高吸水性。另外，比较了芳族二异氰酸酯DDI（4，4二苯基二异氰酸酯）和脂族二异氰酸酯HDI（1，6六亚甲基二异氰酸酯）对交联琼脂性能的功效。通过交联成功地降低了吸水率，与琼脂（206％）相比，DDI和HDI交联琼脂的最小值分别为33.6％和43.6％。观察到DDI交联琼脂（45.3 MPa）的最大抗张强度高于HDI交联琼脂（30.6 MPa）和琼脂（31.7 MPa）。芳族二异氰酸酯交联琼脂在较高温度下表现出更好的耐热性。观察到，由于较高的反应性，芳族二异氰酸酯比脂族二异氰酸酯更有效地交联琼脂。交联的琼脂样品具有血液相容性，并显示出无毒性的细胞增殖特性。