Chiral ansa‐metallocenes are privileged catalysts for a range of stereoselective transformations. Their synthesis, however, has remained a tremendous challenge, which has prevented a broad and systematic exploration for applications in synthesis and catalysis. A modular approach to such ansa‐metallocenes that enables a facile modification of the ring substitution and the ligand bridge, as well as the introduction of various core metals, is described. The complexes were formed with good rac‐selectivity and could be isolated with high purity. The strength of the approach was demonstrated by the synthesis of several new and previously known complexes, including a unique helical chiral ansa‐metallocene. Using a chiral ligand, a moderate central‐to‐planar chirality transfer was observed.

中文翻译：

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定制手性碳桥式茴香醚-金属茂的统一方法

手性ansa-茂金属是一系列立体选择性转化的特有催化剂。然而，它们的合成仍然是巨大的挑战，这阻止了在合成和催化中的应用的广泛而系统的探索。本文介绍了一种用于此类ansa-茂金属的模块化方法，该方法可轻松修饰环取代和配体桥，以及引入各种核心金属。该复合物具有良好的形成消旋-选择性和可高纯度地分离。通过合成几种新的和先前已知的复合物（包括独特的螺旋手性ansa）证明了该方法的优势。茂金属。使用手性配体，观察到适度的中心到平面手性转移。