An Autolytic High Strength Instant Adhesive Hydrogel for Emergency Self‐Rescue,Advanced Functional Materials

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An Autolytic High Strength Instant Adhesive Hydrogel for Emergency Self‐Rescue
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2018-09-06 , DOI: 10.1002/adfm.201804925
Chunyan Cui ₁ , Tengling Wu ₁ , Fei Gao ₁ , Chuanchuan Fan ₁ , Ziyang Xu ₁ , Hongbo Wang ₁ , Bo Liu ₁ , Wenguang Liu ₁

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Adhesive hydrogels are promising to be explored as biomedical sealants, hemostatic agents, and glues in promoting wound healing and tissue regeneration. However, it is challenging to engineer a hydrogel combining instant robust adhesion and high strength. Herein, a high‐strength instantly self‐adhesive organic–inorganic hybrid (OIH) hydrogel by a one‐pot radical polymerization of N‐acryloyl 2‐glycine (ACG), biocompatible glycine derivative vinyl monomer with addition of hydroxyapatite (HAp), naturally occurring mineral is designed and fabricated. The hydrogen bonding from side chain of poly(N‐acryloyl 2‐glycine) (PACG), carboxyl‐Ca²⁺ ionic crosslinking together with PACG chain‐HAp physical interactions contribute to automatic self‐repairing high mechanical properties. Importantly, this OIH hydrogel exhibits robust adhesion to diverse substrates, presumably due to synergistic interactions of carboxyl with the substrate surface and the enhanced contact of PACG chains to adherent surfaces facilitated by HAp nanoparticles. Remarkably, the PACG‐HAp OIH hydrogels can instantly self‐adhere to the soft tissues with adhesion strength of 105 kPa, and anastomose the broken intestines, meanwhile promoting wound healing and stopping bleeding. The OIH hydrogel is autolytic in the body without eliciting inflammatory reaction. Further, the ready‐to‐use PACG‐HAp adhesive hydrogel can be properly stored for a long time. This novel hydrogel will find an appealing application as a new adhesive for emergency self‐rescue.

中文翻译：

用于紧急自救的自溶高强度速溶胶水凝胶

粘性水凝胶有望被用作生物医学密封剂，止血剂和促进伤口愈合和组织再生的胶水。但是，设计出既具有即时稳固的附着力又具有高强度的水凝胶是一项挑战。在此，自然地通过生物相容性甘氨酸衍生物乙烯基单体N-丙烯酰基2-甘氨酸（ACG）的单锅自由基聚合并自然地添加了羟基磷灰石（HAp），制得了高强度的即时自粘有机-无机杂化（OIH）水凝胶。发生的矿物是经过设计和制造的。聚（N-丙烯酰基2-甘氨酸）（PACG），羧基-Ca ^2+的侧链上的氢键离子交联与PACG链-HAp物理相互作用共同促进了自动自我修复的高机械性能。重要的是，这种OIH水凝胶对各种基质均表现出强大的粘附力，这大概是由于羧基与基质表面的协同相互作用以及HAp纳米颗粒促进了PACG链与粘附表面的增强接触。值得注意的是，PACG-HAp OIH水凝胶可立即自粘在软组织上，粘附强度为105 kPa，并吻合肠的破裂，同时促进伤口愈合和止血。OIH水凝胶可在体内自溶而不引起炎症反应。此外，可立即使用的PACG-HAp粘合剂水凝胶可以长期保存。

更新日期：2018-09-06

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