Lipid/chitosan (CS) particle assemblies have recently been developed as new promising carriers for drug delivery applications. The present work reports for the first time the formation of such assemblies by a simple spontaneous adsorption of lipid membranes onto the CS particle surfaces. As shown by dynamic light scattering (DLS) measurements, final non-aggregated assemblies with relatively satisfactory size distributions were obtained by using this process. Furthermore, a particular attention has been paid herein to the effect of the initial morphology of lipid membranes (i.e., vesicular or discoidal) on the resulting characteristics of assemblies. To this end, each one of these membranes was mixed with CS particles, and the obtained assemblies were observed by transmission electron microscopy (TEM). According to these observations, the vesicular lipid membranes seem to wrap mostly CS particles. In contrast, lipid discs are not reorganized onto the particle surface but would rather be stacked onto the CS particle.

脂质/壳聚糖（CS）粒子组件最近已被开发为用于药物输送应用的新的有前途的载体。本工作首次报道了通过脂质膜在CS颗粒表面上的简单自发吸附而形成的此类组件。如动态光散射（DLS）测量所示，通过使用此过程可获得具有相对令人满意的尺寸分布的最终未聚集组件。此外，本文已特别关注脂质膜的初始形态的影响（即，水泡状或盘状）。为此，将这些膜的每一个与CS颗粒混合，并且通过透射电子显微镜（TEM）观察获得的组件。根据这些观察结果，囊状脂质膜似乎主要包裹CS颗粒。相反，脂质盘没有重组到颗粒表面上，而是堆叠在CS颗粒上。