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Palladium(ii)-catalyzed γ-selective hydroarylation of alkenyl carbonyl compounds with arylboronic acids†
Chemical Science ( IF 7.6 ) Pub Date : 2018-09-06 00:00:00 , DOI: 10.1039/c8sc03081b
Rei Matsuura 1 , Tanner C Jankins 1 , David E Hill 1 , Kin S Yang 1 , Gary M Gallego 2 , Shouliang Yang 2 , Mingying He 2 , Fen Wang 2 , Rohan P Marsters 1 , Indrawan McAlpine 2 , Keary M Engle 1
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A catalytic γ-selective syn-hydroarylation of alkenyl carbonyl compounds using arylboronic acids has been developed using a substrate directivity approach with a palladium(II) catalyst. This method tolerates a wide range of functionalized (hetero)arylboronic acids and a variety of substitution patterns on the alkene. Preliminary mechanistic studies suggest that transmetalation is rate-limiting.

中文翻译:

钯 (ii) 催化的烯基羰基化合物与芳基硼酸的 γ-选择性加氢芳基化†

使用芳基硼酸对烯基羰基化合物进行催化γ-选择性顺式加氢芳基化反应,采用底物方向性方法和钯( II )催化剂进行开发。该方法可耐受多种官能化(杂)芳基硼酸和烯烃上的多种取代模式。初步机制研究表明金属转移是限速的。
更新日期:2018-09-06
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