Copper-Catalyzed Radical Relay for Asymmetric Radical Transformations,Accounts of Chemical Research

当前位置： X-MOL 学术 › Acc. Chem. Res. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Copper-Catalyzed Radical Relay for Asymmetric Radical Transformations
Accounts of Chemical Research ( IF 16.4 ) Pub Date : 2018-09-05 00:00:00 , DOI: 10.1021/acs.accounts.8b00265
Fei Wang ₁ , Pinhong Chen ₁ , Guosheng Liu ₁

Affiliation

The direct transformation of C–H bonds into diverse functional groups represents one of the most atom- and step-economical strategies for organic synthesis and has received substantial attention over the last few decades. Despite recent advances, asymmetric C–H bond functionalizations are less developed, especially asymmetric oxidations of sp³ C–H bonds. Inspired by enzyme (e.g., P450) catalysis, chemists have made great efforts to develop non-enzymatic systems for enantioselective oxidations of sp³ C–H bonds. However, the involvement of highly reactive radical intermediates makes enantioselective transformations extremely challenging.

中文翻译：

用于不对称自由基转换的铜催化自由基继电器

将C–H键直接转化为各种官能团是有机合成中最原子和最经济的策略之一，并且在过去的几十年中受到了广泛的关注。尽管有最新进展，但不对称的C–H键功能化尚不发达，特别是sp ³ C–H键的不对称氧化。受酶（例如P450）催化的启发，化学家们为开发非酶系统（用于sp ³ C–H键的对映选择性氧化）付出了巨大的努力。然而，高反应性自由基中间体的参与使得对映选择性转化极具挑战性。

更新日期：2018-09-05

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11