Alpha-Synuclein Nitration and Its Implications in Parkinson's Disease.,ACS Chemical Neuroscience

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Alpha-Synuclein Nitration and Its Implications in Parkinson's Disease.
ACS Chemical Neuroscience ( IF 4.1 ) Pub Date : 2018-09-17 , DOI: 10.1021/acschemneuro.8b00288
Yixi He ₁ , Zhongwang Yu ₂ , Shengdi Chen ₁

Affiliation

Parkinson's disease is pathologically characterized by the degeneration of dopaminergic neurons in the substantia nigra and the accumulation of neuronal cytoplasmic inclusions known as Lewy bodies, which are primarily composed of α-synuclein. Post-translational modifications of α-synuclein induced by nitrative stress have been linked to neurodegeneration. Here, we review the concept of α-synuclein nitration and its biological consequences. We also discuss the pathological roles of nitrated α-synuclein and their potential clinical implications in Parkinson's disease.

中文翻译：

α-突触核蛋白的硝化作用及其在帕金森氏病中的意义。

帕金森氏病的病理学特征是黑质中多巴胺能神经元的变性和称为路易小体的神经元胞质内含物的积累，其主要由α-突触核蛋白组成。由硝化应激诱导的α-突触核蛋白的翻译后修饰与神经变性有关。在这里，我们回顾了α-突触核蛋白硝化的概念及其生物学后果。我们还讨论了硝化α-突触核蛋白的病理作用及其在帕金森氏病中的潜在临床意义。

更新日期：2018-09-05

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