Silanized hydroxypropyl methylcellulose based hydrogels were developed for cartilage and intervertebral disc tissue engineering. Herein, study of dynamics of confined water showed two different populations, identified as hydration and bulk-like water. The diffusion coefficient showed that bulk-like water diffuses over distances ~10 µm without being affected by the hydrogel matrix. Addition of silica nanofibers leads to improved mechanical properties and enhanced diffusion coefficient. Good diffusion within hydrogels is essential for the application.

中文翻译：

---

专为组织工程设计的硅烷化羟丙基甲基纤维素基水凝胶的水动力学

基于硅烷化的羟丙基甲基纤维素的水凝胶被开发用于软骨和椎间盘组织工程。在这里，对承压水动力学的研究显示了两个不同的种群，分别是水化​​水和大块状水。扩散系数表明，大块状水在〜10 µm的距离内扩散而不受水凝胶基质的影响。二氧化硅纳米纤维的添加导致改善的机械性能和增强的扩散系数。水凝胶内的良好扩散对于应用至关重要。