Stent implantation at a highly curved artery has always been a challenge, considering the relatively high chance of in-stent restenosis (ISR) caused by severe straightening effect and high strain energy over the vessel wall. In this paper, a novel optimization based design method was proposed to manipulate the deformation behavior of the common ring-and-link stent. By changing the location of the connection point between rings and links, traditional ring-and-link structure was modified to achiever tunable Poisson's ratio (PR). With the nonuniform cellular structure design method proposed in a previous study, PR distribution of the stent structure was optimized to achieve the desired curvature. As a result, the obtained stent structure with nonuniform PR could perfectly fit into the curved artery after expansion, without causing any obvious vessel straightening. To validate the proposed method, two different vessel models were introduced. Firstly, a short vessel with a constant curvature was set as the design objective, and both numerical and experimental tests were conducted. Further, a patient-specific vessel was applied. Both test results showed that optimized stents would cause much smaller vessel straightening. Moreover, vessels stented by the optimized structures had much lower stress concentration and strain energy. All those properties will decrease the possibility of ISR significantly.

考虑到由严重的矫直作用和血管壁上的高应变能引起的支架内再狭窄（ISR）的机会相对较高，在高度弯曲的动脉处植入支架一直是一个挑战。本文提出了一种基于优化的新颖设计方法来控制普通环环支架的变形行为。通过更改环和链接之间的连接点的位置，对传统的环和链接结构进行了修改，以实现可调节的泊松比（PR）。使用先前研究中提出的非均匀孔结构设计方法，可以优化支架结构的PR分布以实现所需的曲率。结果，获得的具有不均匀PR的支架结构可以在扩张后完全适合弯曲动脉，不会导致任何明显的血管矫直。为了验证所提出的方法，引入了两种不同的容器模型。首先，将曲率恒定的短容器作为设计目标，并进行了数值和实验测试。此外，应用了患者专用的血管。两项测试结果均表明，优化的支架将导致更小的血管矫直。而且，通过优化结构置入支架的血管具有更低的应力集中和应变能。所有这些特性将显着降低ISR的可能性。应用了特定于患者的血管。两项测试结果均表明，优化的支架将导致更小的血管矫直。而且，通过优化结构置入支架的血管具有较低的应力集中和应变能。所有这些特性将显着降低ISR的可能性。应用了特定于患者的血管。两项测试结果均表明，优化的支架将导致更小的血管矫直。而且，通过优化结构置入支架的血管具有较低的应力集中和应变能。所有这些特性将显着降低ISR的可能性。