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In vivo reprogramming of wound-resident cells generates skin epithelial tissue
Nature ( IF 50.5 ) Pub Date : 2018-09-01 , DOI: 10.1038/s41586-018-0477-4 Masakazu Kurita 1, 2 , Toshikazu Araoka 1, 3 , Tomoaki Hishida 1 , David D O'Keefe 1 , Yuta Takahashi 1 , Akihisa Sakamoto 1, 3 , Masahiro Sakurai 1, 3 , Keiichiro Suzuki 1 , Jun Wu 1 , Mako Yamamoto 1 , Reyna Hernandez-Benitez 1 , Alejandro Ocampo 1 , Pradeep Reddy 1 , Maxim Nikolaievich Shokhirev 4 , Pierre Magistretti 5 , Estrella Núñez Delicado 3 , Hitomi Eto 2 , Kiyonori Harii 2 , Juan Carlos Izpisua Belmonte 1
Nature ( IF 50.5 ) Pub Date : 2018-09-01 , DOI: 10.1038/s41586-018-0477-4 Masakazu Kurita 1, 2 , Toshikazu Araoka 1, 3 , Tomoaki Hishida 1 , David D O'Keefe 1 , Yuta Takahashi 1 , Akihisa Sakamoto 1, 3 , Masahiro Sakurai 1, 3 , Keiichiro Suzuki 1 , Jun Wu 1 , Mako Yamamoto 1 , Reyna Hernandez-Benitez 1 , Alejandro Ocampo 1 , Pradeep Reddy 1 , Maxim Nikolaievich Shokhirev 4 , Pierre Magistretti 5 , Estrella Núñez Delicado 3 , Hitomi Eto 2 , Kiyonori Harii 2 , Juan Carlos Izpisua Belmonte 1
Affiliation
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Large cutaneous ulcers are, in severe cases, life threatening1,2. As the global population ages, non-healing ulcers are becoming increasingly common1,2. Treatment currently requires the transplantation of pre-existing epithelial components, such as skin grafts, or therapy using cultured cells2. Here we develop alternative supplies of epidermal coverage for the treatment of these kinds of wounds. We generated expandable epithelial tissues using in vivo reprogramming of wound-resident mesenchymal cells. Transduction of four transcription factors that specify the skin-cell lineage enabled efficient and rapid de novo epithelialization from the surface of cutaneous ulcers in mice. Our findings may provide a new therapeutic avenue for treating skin wounds and could be extended to other disease situations in which tissue homeostasis and repair are impaired.Four transcription factors that specify keratinocyte cell fate, facilitate in vivo reprogramming of wound-resident mesenchymal cells, epithealization and regeneration of skin epithelial tissues in mice.
中文翻译：
伤口驻留细胞的体内重编程产生皮肤上皮组织
在严重的情况下，大的皮肤溃疡会危及生命 1,2。随着全球人口老龄化，无法愈合的溃疡越来越普遍 1,2。目前的治疗需要移植预先存在的上皮成分，例如皮肤移植物，或使用培养细胞进行治疗2。在这里，我们开发了用于治疗此类伤口的替代表皮覆盖材料。我们使用伤口驻留间充质细胞的体内重编程生成可扩张的上皮组织。指定皮肤细胞谱系的四种转录因子的转导使得小鼠皮肤溃疡表面能够高效快速地从头上皮化。
更新日期：2018-09-01
中文翻译：
伤口驻留细胞的体内重编程产生皮肤上皮组织
在严重的情况下，大的皮肤溃疡会危及生命 1,2。随着全球人口老龄化，无法愈合的溃疡越来越普遍 1,2。目前的治疗需要移植预先存在的上皮成分，例如皮肤移植物，或使用培养细胞进行治疗2。在这里，我们开发了用于治疗此类伤口的替代表皮覆盖材料。我们使用伤口驻留间充质细胞的体内重编程生成可扩张的上皮组织。指定皮肤细胞谱系的四种转录因子的转导使得小鼠皮肤溃疡表面能够高效快速地从头上皮化。
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