Gold nanoparticles are commonly used for medical applications such as drug delivery and as therapeutic and diagnostic materials because of their unique properties. In this study, we prepared docetaxel (DTX)-loaded hyaluronic acid–cleavable-peptide–gold nanoparticles for the treatment of cancer by selectively delivering DTX into the tumor and, thus, enhancing the therapeutic effect of DTX; further, we determined synergistic effects of the nanoparticles using laser treatment. The DTX-loaded hyaluronic acid–cleavable-peptide–gold nanoparticles prepared in this study had an average size of 75 nm and negative surface charge. The nanoparticles revealed greater cytotoxicity and higher tumor suppression efficacy in tumor models than free DTX under near-infrared laser irradiation. Therefore, the nanoparticle formulation prepared in this study could be utilized for targeted drug delivery and in combination with other cancer therapies.

中文翻译：

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装载多西他赛的透明质酸-组织蛋白酶B-可裂解肽-金纳米颗粒治疗癌症

金纳米颗粒由于其独特的性能而通常用于医学应用，例如药物递送以及用作治疗和诊断材料。在这项研究中，我们制备了装载多西他赛（DTX）的透明质酸-可裂解肽-金纳米颗粒，用于通过选择性地将DTX递送到肿瘤中从而增强DTX的治疗效果来治疗癌症。此外，我们使用激光处理确定了纳米颗粒的协同效应。这项研究中制备的DTX负载的透明质酸-可裂解肽-金纳米颗粒的平均粒径为75 nm，表面带负电。与游离DTX相比，在近红外激光照射下，纳米颗粒在肿瘤模型中显示出更大的细胞毒性和更高的肿瘤抑制功效。所以，