Liposomes and polymersomes: a comparative review towards cell mimicking,Chemical Society Reviews

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Liposomes and polymersomes: a comparative review towards cell mimicking
Chemical Society Reviews ( IF 40.4 ) Pub Date : 2018-09-04 00:00:00 , DOI: 10.1039/c8cs00162f
Emeline Rideau _{1,

2,

3} , Rumiana Dimova _{3,

4,

5,

6} , Petra Schwille _{3,

7,

8} , Frederik R. Wurm _{1,

2,

3} , Katharina Landfester _{1,

2,

3}

Affiliation

Cells are integral to all forms of life due to their compartmentalization by the plasma membrane. However, living organisms are immensely complex. Thus there is a need for simplified and controllable models of life for a deeper understanding of fundamental biological processes and man-made applications. This is where the bottom-up approach of synthetic biology comes from: a stepwise assembly of biomimetic functionalities ultimately into a protocell. A fundamental feature of such an endeavor is the generation and control of model membranes such as liposomes and polymersomes. We compare and contrast liposomes and polymersomes for a better a priori choice and design of vesicles and try to understand the advantages and shortcomings associated with using one or the other in many different aspects (properties, synthesis, self-assembly, applications) and which aspects have been studied and developed with each type and update the current development in the field.

中文翻译：

脂质体和聚合体：细胞模拟的比较审查。

由于细胞被质膜分隔，因此它们是所有生命形式不可或缺的部分。但是，生物非常复杂。因此，需要一种简化且可控制的生命模型，以更深入地了解基本的生物学过程和人为应用。这是合成生物学的自下而上方法的来源：仿生功能的逐步组装，最终组装到了原生细胞中。这种努力的基本特征是模型膜如脂质体和聚合物体的产生和控制。我们比较和对比脂质体和聚合体，以获得更好的先验性 选择和设计囊泡，并尝试了解在许多不同方面（属性，合成，自组装，应用程序）中使用一个或另一个相关的优点和缺点，以及每种类型已经研究和开发的方面并更新了当前在该领域的发展。

更新日期：2018-09-04

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