Sydnone-coumarins as clickable turn-on fluorescent sensors for molecular imaging†,Chemical Communications

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Sydnone-coumarins as clickable turn-on fluorescent sensors for molecular imaging†
Chemical Communications ( IF 4.3 ) Pub Date : 2018-09-03 00:00:00 , DOI: 10.1039/c8cc06070c
Elodie Decuypère _{1,

2,

3,

4,

5} , Margaux Riomet _{1,

2,

3,

4,

5} , Antoine Sallustrau _{1,

2,

3,

4,

5} , Sarah Bregant _{3,

4,

5,

6} , Robert Thai _{3,

4,

5,

6} , Grégory Pieters _{1,

2,

3,

4,

5} , Gilles Clavier _{3,

5,

7,

8,

9} , Davide Audisio _{1,

2,

3,

4,

5} , Frédéric Taran _{1,

2,

3,

4,

5}

Affiliation

Copper-catalyzed and copper-free sydnone–alkyne cycloaddition reactions have emerged as complementary click tools for chemical biology but their use in bioorthogonal labeling is still in its infancy. Herein, combinations of alkynes and coumarin-sydnones were screened for their ability to generate pyrazole products displaying strong fluoroscence enhancement compared to reactants. One sydnone was identified as a particularly suitable new turn-on probe for protein labeling.

中文翻译：

Sydnone-香豆素可作为分子成像中可点击的开启式荧光传感器†

铜催化的和无铜的亚砜-炔烃环加成反应已经成为化学生物学的补充点击工具，但它们在生物正交标记中的应用仍处于起步阶段。在此，对炔烃和香豆素-sydnones的组合进行筛选，以确定它们与反应物相比具有产生强烈荧光增强作用的吡唑产物的能力。一个sydnone被确定为特别适合蛋白质标记的新型开启探针。

更新日期：2018-09-03

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