Copper-Catalyzed Synthesis of Substituted 4-Acylpyrazole Derivatives through a Cascade Transformation from N-Propargylic Sulfonylhydrazones and Diaryliodonium Salts,Synlett

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Copper-Catalyzed Synthesis of Substituted 4-Acylpyrazole Derivatives through a Cascade Transformation from N-Propargylic Sulfonylhydrazones and Diaryliodonium Salts
Synlett ( IF 1.7 ) Pub Date : 2018-09-03 , DOI: 10.1055/s-0037-1610271
Yi-Hui Chen ₁ , Ren-Hao Li ₁ , Xin-Yang Fan ₁ , Zi-Lin Hu ₁ , Zhi-Kai Liu ₁ , Ying Yang ₁ , Hai-Tao Tang ₂ , Li Chen ₁ , Zhuang-Ping Zhan ₁

Affiliation

A concise strategy for the synthesis of substituted 4-acylpyrazole derivatives from N-propargylic sulfonylhydrazones and diaryliodonium salts has been developed. The pyrazole derivatives are formed through a five-step cascade sequence that includes intramolecular cyclization, hydroxylation, elimination, copper-catalyzed aerobic oxidation, and intramolecular rearrangement.

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