Rheumatoid arthritis is a common chronic inflammatory disorder and a major cause of disability. Despite the progress made with recent clinical use of anti-cytokine biologics, the response rate of rheumatoid arthritis treatment remains unsatisfactory, owing largely to the complexity of cytokine interactions and the multiplicity of cytokine targets. Here, we show a nanoparticle-based broad-spectrum anti-inflammatory strategy for rheumatoid arthritis management. By fusing neutrophil membrane onto polymeric cores, we prepare neutrophil membrane-coated nanoparticles that inherit the antigenic exterior and associated membrane functions of the source cells, which makes them ideal decoys of neutrophil-targeted biological molecules. It is shown that these nanoparticles can neutralize proinflammatory cytokines, suppress synovial inflammation, target deep into the cartilage matrix, and provide strong chondroprotection against joint damage. In a mouse model of collagen-induced arthritis and a human transgenic mouse model of arthritis, the neutrophil membrane-coated nanoparticles show significant therapeutic efficacy by ameliorating joint damage and suppressing overall arthritis severity.

类风湿关节炎是一种常见的慢性炎性疾病，也是致残的主要原因。尽管最近在临床上使用抗细胞因子生物制剂取得了进展，但由于细胞因子相互作用的复杂性和细胞因子靶标的多样性，类风湿性关节炎治疗的反应率仍然不能令人满意。在这里，我们显示了基于纳米粒子的类风湿关节炎治疗的广谱抗炎策略。通过将嗜中性白细胞膜融合到聚合物核上，我们制备了嗜中性白细胞膜包被的纳米颗粒，这些颗粒继承了源细胞的抗原性外部和相关的膜功能，这使其成为靶向嗜中性白细胞的生物分子的理想诱饵。结果表明，这些纳米粒子可以中和促炎细胞因子，抑制滑膜炎症，靶向软骨基质深处，并提供强大的软骨保护以防止关节损伤。在胶原诱导的关节炎的小鼠模型和关节炎的人类转基因小鼠模型中，中性粒细胞膜包被的纳米颗粒通过减轻关节损伤和抑制整体关节炎的严重性而显示出显着的治疗功效。