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Effects of cafeteria diet on memory and hippocampal oxidative stress in a rat model of Alzheimer-like disease: Neuroprotection of green tea supplementation
Journal of Functional Foods ( IF 3.8 ) Pub Date : 2018-09-01 , DOI: 10.1016/j.jff.2018.08.026
Helen L. Schimidt , Alexandre Garcia , Alexandre Martins , Marisa Garcia , Melina B. Soares , Francielli W. Cibin , Pamela B. Mello-Carpes , Felipe P. Carpes

Here we investigate the neuroprotective role of green tea (GT) when cafeteria diet (CAF) is associated with a model of β-Amyloid (Aβ) injection that induces cognitive impairments related to Alzheimer disease (AD). Wistar male rats were supplemented with GT, CAF, or GT plus CAF for 8 weeks before intra-hippocampal injection of Aβ peptide (2 μL of Aβ-25–35, CA1 region). AD-like and sham rats were submitted to memory tests. Oxidative status was quantified in the bilateral hippocampus, and plasmatic triglycerides, total cholesterol, glucose, and AChE activity were determined. CAF per se does not impair object and social recognition memories. Neuroprotective role of GT was confirmed also in the conditions of CAF combined with AD-like. GT supplementation and CAF, either isolated or combined, avoid oxidative stress and damage in the hippocampus. We conclude that CAF did not influence oxidative damage and memory deficits resultant of β-Amyloid injection when GT is simultaneously ingested.



中文翻译:

食堂饮食对阿尔茨海默病样大鼠模型记忆和海马氧化应激的影响:绿茶补充剂的神经保护作用

在这里,我们研究自助餐厅饮食(CAF)与诱导与阿尔茨海默病(AD)相关的认知障碍的β-淀粉样蛋白(Aβ)注射模型相关的绿茶(GT)的神经保护作用。在海马内注射Aβ肽(2μLAβ-25-35,CA1区)之前,Wistar雄性大鼠补充GT,CAF或GT加CAF 8周。将类似AD的大鼠和假大鼠进行记忆测试。定量双侧海马的氧化状态,并测定血浆甘油三酸酯,总胆固醇,葡萄糖和AChE活性。CAF本身不会损害对象和社会认可的记忆。在CAF合并AD样的情况下,也证实了GT的神经保护作用。单独或联合使用GT补充剂和CAF可以避免氧化应激和海马损伤。

更新日期:2018-09-01
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