A series of sixteen triphenyl Bi(V) and Sb(V) acetato complexes of general formula [MPh₃(O₂CCR)₂] and one oxido-bridge antimony complex [(SbPh₃(O₂COC(O)Me))₂O], have been synthesised and characterised, thirteen of which are novel. The solid-state structures of fifteen of the complexes have been successfully authenticated by single crystal X-ray diffraction. All structures, excluding the oxido-bridge antimony complex, adopt a typical trigonal bipyramidal confirmation with the phenyl rings in a propeller-like orientation in the equatorial plane. Fourteen of the complexes were screened for their anti-leishmanial activity and cytotoxicity towards mammalian cells. The Bi(V) complexes were found to be unstable in DMEM culture media and to be severely toxic towards mammalian cells, with IC₅₀ values in the range 11.4 μM–19.8 μM. In contrast, the Sb(V) complexes demonstrated a high degree of stability and selectivity, with IC₅₀ values 6.18–19.1 μM for the promastigote assay, and of 73.8–≤100 μM for the human fibroblasts. Assessment of the Sb(V) complexes against the clinically relevant amastigote form of these parasites at 10 μM showed all but the oxido-bridged complex to be effective, with % infection values ranging from 7.0 ± 1.7–40.5 ± 2.0.

一系列十六种通式为[MPh ₃（O ₂ CCR）₂ ]的三苯基Bi（V）和Sb（V）醋酸盐配合物和一个氧化桥锑配合物[（SbPh ₃（O ₂ C O C（O）Me ））₂O]，已经合成和表征，其中13种是新颖的。15种配合物的固态结构已通过单晶X射线衍射成功鉴定。除氧化桥锑络合物外，所有结构均采用典型的三角双锥体确认，其苯环在赤道平面内呈螺旋桨状。筛选了十四种复合物的抗leishmanial活性和对哺乳动物细胞的细胞毒性。发现Bi（V）复合物在DMEM培养基中不稳定，对哺乳动物细胞有严重毒性，IC ₅₀值在11.4 μM–19.8μM范围内。相比之下，Sb（V）配合物表现出高度的稳定性和选择性，IC ₅₀假前鞭毛虫的检测值为6.18–19.1μM，人成纤维细胞的检测值为73.8–≤100μM。对这些寄生虫的临床相关的鞭毛体形式的Sb（V）复合物进行评估，其浓度为10μM，除氧化桥复合物外，其他所有复合物均有效，％感染值范围为7.0±1.7–40.5±2.0。