The X-linked deubiquitinase, USP9X, is implicated in multiple cancers by targeting various substrates. Increased expression of USP9X is observed in non-small-cell lung cancer (NSCLC) and is correlated with poor prognosis. However, the molecular mechanism for USP9X regulation of tumor cell survival and tumorigenesis in NSCLC is less defined.

中文翻译：

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新型USP9X底物TTK有助于非小细胞肺癌的肿瘤发生

X连锁的去泛素酶USP9X通过靶向多种底物而与多种癌症有关。在非小细胞肺癌（NSCLC）中观察到USP9X表达增加，并且与不良预后相关。但是，USP9X调节非小细胞肺癌中肿瘤细胞存活和肿瘤发生的分子机制尚不清楚。