Resveratrol counteracts bone loss via mitofilin-mediated osteogenic improvement of mesenchymal stem cells in senescence-accelerated mice,Theranostics

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Resveratrol counteracts bone loss via mitofilin-mediated osteogenic improvement of mesenchymal stem cells in senescence-accelerated mice
Theranostics ( IF 12.4 ) Pub Date : 2018-03-23 , DOI: 10.7150/thno.23620
Ya-Jie Lv _{1,

2} , Yi Yang _{1,

3} , Bing-Dong Sui _{1,

4} , Cheng-Hu Hu _{1,

4} , Pan Zhao _{1,

4} , Li Liao _{1,

4} , Ji Chen ₁ , Li-Qiang Zhang _{1,

4} , Tong-Tao Yang ₅ , Shao-Feng Zhang ₃ , Yan Jin _{1,

4}

Affiliation

Rational: Senescence of mesenchymal stem cells (MSCs) and the related functional decline of osteogenesis have emerged as the critical pathogenesis of osteoporosis in aging. Resveratrol (RESV), a small molecular compound that safely mimics the effects of dietary restriction, has been well documented to extend lifespan in lower organisms and improve health in aging rodents. However, whether RESV promotes function of senescent stem cells in alleviating age-related phenotypes remains largely unknown. Here, we intend to investigate whether RESV counteracts senescence-associated bone loss via osteogenic improvement of MSCs and the underlying mechanism.

中文翻译：

白藜芦醇通过 mitofilin 介导的衰老加速小鼠间充质干细胞成骨改善来抵消骨质流失

理由：间充质干细胞（MSCs）的衰老和相关的成骨功能下降已成为衰老过程中骨质疏松症的关键发病机制。白藜芦醇 (RESV) 是一种小分子化合物，可以安全地模拟饮食限制的影响，已被充分证明可以延长低等生物的寿命并改善衰老啮齿动物的健康。然而，RESV 是否促进衰老干细胞在减轻与年龄相关的表型方面的功能仍然很大程度上未知。在这里，我们打算研究 RESV 是否通过 MSCs 的成骨改善及其潜在机制来抵消衰老相关的骨丢失。

更新日期：2018-09-01

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