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Asymmetric Construction of Halogenated Cyclic Quaternary Carbon Center through Enolate Activation of Aldehydes
Synlett ( IF 1.7 ) Pub Date : 2018-08-31 , DOI: 10.1055/s-0037-1610256
Jun-Long Li 1 , Qing-Zhu Li , Yue Liu , Hai-Jun Leng
Affiliation  

The construction of a chiral halogenated cyclic quaternary carbon center through various catalytic strategies is an emerging hot topic in the field of asymmetric synthesis. Herein, we give a summary of recently developed synthetic methods for preparing such structures. In addition, a novel enolate activation mode of aldehydes is highlighted, which provides an elegant pathway to access enantiopure heterocycles featuring a halogenated quaternary stereocenter through organocatalytic [4+2] cycloaddition.

中文翻译:

醛的烯醇化活化不对称构建卤代环季碳中心

通过各种催化策略构建手性卤代环状季碳中心是不对称合成领域的一个新兴热点。在此,我们总结了最近开发的用于制备此类结构的合成方法。此外,还强调了醛的一种新的烯醇化物活化模式,它提供了一种优雅的途径,可以通过有机催化的 [4+2] 环加成反应获得具有卤代四元立体中心的对映纯杂环。
更新日期:2018-08-31
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