Natural life is encoded by evolvable, DNA-based memory. Recent advances in dynamic genome-engineering technologies, which we collectively refer to as in vivo DNA writing, have opened new avenues for investigating and engineering biology. This Review surveys these technological advances, outlines their prospects and emerging applications, and discusses the features and current limitations of these technologies for building various genetic circuits for processing and recording information in living cells.

中文翻译：

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DNA 写入器和分子记录器的新兴应用

自然生命是由可进化的、基于 DNA 的记忆编码的。动态基因组工程技术（我们统称为体内 DNA 写入）的最新进展为研究和工程生物学开辟了新的途径。本综述调查了这些技术进步，概述了它们的前景和新兴应用，并讨论了这些技术的特点和当前的局限性，这些技术用于构建各种遗传电路来处理和记录活细胞中的信息。