Alzheimer's disease (AD) is characterized by a progressive neurodegenerative disorder and there is no effective treatment to delay disease progression. Our study was to examine potential protection mechanisms by administering 2% grape powder or 2% grape powder modified by high hydrostatic pressure (HHP) diets to APP/PS1 mice for 24 weeks. The grape supplementation altered APP processing by increasing ADAM10 expression and reducing BACE1 and PS1 expression in the hippocampus and cerebral cortex, which therefore improved cognitive deficits in mice. The levels of TNF-α and IL-1β were remarkably decreased in serum and hippocampus by grape supplementation. Furthermore, there was a significant enhancement of SOD activities and reduction of MDA levels in the hippocampus of APP/PS1 mice treated with grape supplementation. Our findings indicated that grape supplementation could be an effective approach for AD intervention, which might be associated with altering APP processing, inhibiting inflammation responses, and enhancing antioxidant capacity.

阿尔茨海默氏病（AD）的特征是进行性神经退行性疾病，没有有效的治疗方法可延缓疾病的进展。我们的研究旨在通过将2％的葡萄粉或2％的经高静水压（HHP）饮食改性的葡萄粉给予APP / PS1小鼠24周来检查其潜在的保护机制。葡萄补充剂通过增加海马和大脑皮层中ADAM10的表达并减少BACE1和PS1的表达来改变APP的加工过程，从而改善了小鼠的认知缺陷。补充葡萄后，血清和海马中的TNF-α和IL-1β水平明显降低。此外，用葡萄补充剂处理的APP / PS1小鼠的海马中SOD活性显着增强，MDA水平降低。