Starting from the 21st century, breast cancer can be classified as the most common invasive malignancy in women. Among the preventive or therapeutic strategies of breast cancer, combination therapy is the most promising approach. This mode of treatment of breast cancer concurrently maximizes efficacy, overcomes multidrug resistance, and minimizes harmful side effects caused by radiotherapy and chemotherapy alone. The risk of cancer can be reduced by supplementing diets with naturally occurring products known as phytochemicals. These phytochemicals have well‐defined roles in the management of every stage of breast carcinogenesis. In this review, the collective data of dietary phytochemicals used to sensitize breast cancer cells to therapeutic approaches are reported and their specific molecular targets through synergistic, additive, and potentiation effects are highlighted. The concept of combining natural agents with medicines to augment therapeutic responses creates an optimal modality, which may facilitate clinical applications of combination regimens in the future.

中文翻译：

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通过天然植物化学物质预防乳腺癌：以分子靶标和联合策略为重点

从21世纪开始，乳腺癌可以归类为女性中最常见的浸润性恶性肿瘤。在乳腺癌的预防或治疗策略中，联合治疗是最有前途的方法。这种乳腺癌的治疗方式可同时使功效最大化，克服多药耐药性，并使单独由放疗和化学疗法引起的有害副作用最小化。可以通过在饮食中添加天然存在的被称为植物化学物质的产品来降低患癌症的风险。这些植物化学物质在乳癌发生的每个阶段的管理中都有明确的作用。在这篇评论中，报告了用于使乳腺癌细胞对治疗方法敏感的饮食植物化学物质的集体数据，并通过协同，累加，和增强效果突出显示。将天然药物与药物结合以增强治疗效果的概念创造了一种最佳的治疗方式，这可能会在将来促进联合治疗方案的临床应用。