The paper presents novel Lomefloxacin delivery systems based on heteroatom modified MCM-41-type silica materials. The modification of MCM-41 mesoporous silica with Mg, Fe, Ce or Zn was performed by ion-exchange approach and the resulted materials exhibited an ordered pore framework, high specific surface area (in the range of 510–813 m²/g), total pore volume (from 0.47 to 0.96 cm³/g), and uniform distribution of heteroatoms, which allow their use as carriers in drug delivery systems. The heteroatom modification of MCM-41 silica led either to the formation of amorphous metal oxide on the inner pore surface in the case of Mg and Zn, or materials with a crystalline oxide phase (CeO₂ or Fe₂O₃) on the silica surface. The drug release profiles from heteroatom modified MCM-41 carriers were determined in simulated body fluid pH 7.4 and all Lomefloxacin-loaded samples exhibited a slower release kinetics than the antibiotic dissolution, the lowest delivery rate being obtained for Mg-modified MCM-41 material. All the prepared antibiotic delivery systems presented good bactericide activity against E. coli strain.

本文介绍了基于杂原子修饰的MCM-41型二氧化硅材料的新型洛美沙星递送系统。通过离子交换法对MCM-41介孔二氧化硅进行Mg，Fe，Ce或Zn改性，所得材料显示出有序的孔骨架，高比表面积（在510-813 m ² / g范围内） ，总孔体积（从0.47至0.96 cm ³ / g）和杂原子的均匀分布，这使其可以在药物递送系统中用作载体。MCM-41二氧化硅的杂原子改性导致在Mg和Zn情况下在内孔表面上形成非晶态金属氧化物，或导致具有结晶氧化物相（CeO ₂或Fe ₂ O _{3）的材料}）在二氧化硅表面上。在模拟的体液pH 7.4中确定了杂原子修饰的MCM-41载体的药物释放曲线，所有装载洛美沙星的样品均显示出比抗生素溶出慢的释放动力学，其中Mg修饰的MCM-41材料的释放速率最低。所有制备的抗生素递送系统均表现出良好的针对大肠杆菌菌株的杀菌活性。