Paclitaxel is a well-known cancer drug that functions as a mitotic inhibitor. This work focuses on a copper based crystal that encapsulates the pharmaceutical agent and serves as a drug delivery agent. A Copper₁₀-Pacitaxil₁ chloride (CU₁₀PAC₁) complex is synthesized and tested against the National Cancer Institute’s sixty cell line panel. The 10:1 ratio results in a crystal that was examined by Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spec (MALDI-TOF-MS), Scanning Electron Microscopy (SEM) and Proton (¹H) and Carbon (¹³C) Nuclear Magnetic Resonance (NMR). The potential attributes of a copper based crystal as an in vivo drug carrier for Paclitaxel are discussed.

紫杉醇是众所周知的抗有丝分裂抑制剂的抗癌药物。这项工作的重点是铜基晶体，该晶体封装了药剂并用作药物输送剂。合成了铜_10-紫杉醇₁氯化物（CU ₁₀ PAC ₁）复合物，并针对美国国家癌症研究所的60细胞系专家小组进行了测试。比例为10：1的晶体通过基质辅助激光解吸电离飞行时间质谱（MALDI-TOF-MS），扫描电子显微镜（SEM）和质子（¹ H）和碳（¹³ C ）核磁共振（NMR）。铜基晶体在体内的潜在属性 紫杉醇的药物载体进行了讨论。