Metal–Organic Framework Nanoshuttle for Synergistic Photodynamic and Low‐Temperature Photothermal Therapy,Advanced Functional Materials

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Metal–Organic Framework Nanoshuttle for Synergistic Photodynamic and Low‐Temperature Photothermal Therapy
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2018-08-31 , DOI: 10.1002/adfm.201804634
Kai Zhang _{1,

2,

3} , Xiangdan Meng _{1,

2} , Yu Cao _{1,

2} , Zhou Yang ₃ , Haifeng Dong _{1,

2} , Yuedong Zhang _{1,

2} , Huiting Lu _{1,

2} , Zhuojie Shi ₃ , Xueji Zhang _{1,

2}

Affiliation

Porous metal–organic frameworks (MOFs) nanostructures constructed from metal ion/ion clusters and organic bridging ligands hold great promise for biomedicine applications. The developing of nanoagents achieving accurate diagnosis and improved therapeutic effect is highly desirable. Herein, a new‐style versatile zirconium‐ferriporphyrin metal–organic framework (Zr‐FeP MOF) nanoshuttles is reported using a facile one‐pot hydrothermal method. The Zr‐FeP MOF nanoshuttles enable simultaneously to generate abundant reactive oxygen species including hydroxyl radical (·OH) and singlet oxygen (¹O₂) under a near‐infrared (NIR) laser irradiation. Significant photothermal effect of Zr‐FeP MOF nanoshuttles with photothermal conversion efficiency high to 33.7% is also demonstrated. Under a single NIR laser irradiation, the Zr‐FeP MOF nanoshuttles loaded with heat shock protein 70 siRNA efficiently suppress the tumor growth both in vitro and in vivo owing to the synergistic effect of photodynamic therapy (PDT) and low‐temperature photothermal therapy (PTT). Meanwhile, it exhibits good photothermal imaging, computed tomography, and photoacoustic imaging tri‐mode tumor‐specific imaging capability for tumor accurate diagnosis. This work contributes to design “all‐in‐one” nanoagents that realize multimodal imaging diagnosis and PDT and low‐temperature PTT synergistic treatments.

中文翻译：

金属-有机骨架纳米航天飞机，用于协同光动力和低温光热疗法

由金属离子/离子簇和有机桥联配体构成的多孔金属-有机骨架（MOF）纳米结构在生物医学应用中具有广阔的前景。非常需要开发能够准确诊断和改善治疗效果的纳米剂。在本文中，据报道，一种新型的通用型锆铁金属卟啉金属有机骨架（Zr-FeP MOF）纳米航天飞机采用了一种简便的单锅水热法。Zr-FeP MOF纳米梭可同时产生大量的活性氧，包括羟基自由基（·OH）和单线态氧（¹ O ₂）在近红外（NIR）激光照射下。Zr-FeP MOF纳米梭具有显着的光热效应，光热转化效率高达33.7％。在单次NIR激光照射下，由于光动力疗法（PDT）和低温光疗（PTT）的协同作用，载有热激蛋白70 siRNA的Zr-FeP MOF纳米穿梭物有效地抑制了体内和体外的肿瘤生长。）。同时，它具有良好的光热成像，计算机断层扫描和光声成像三态肿瘤特异性成像能力，可准确诊断肿瘤。这项工作有助于设计“多合一”纳米剂，该纳米剂可实现多模式成像诊断以及PDT和低温PTT协同治疗。

更新日期：2018-08-31

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