Zinc pyrithione (ZnPT) is an organometallic biocide with bactericide, algaecide, and fungicide activity. Considering this biological activity, ZnPT has been used in anti-fouling paints, and also in human therapeutics and cosmetics, in shampoos to treat dandruff and seborrhoea. Despite its potential uses and consequent presence in the aquatic environment, the ecotoxicological effects of ZnPT are poorly understood. This work aims to characterise the effects of ZnPT in biochemical parameters of the Asian clam, one of the most invasive bivalves known for its biofouling action in hydro-dependent industries, using a classical (LC₅₀ determination) and a biomarker-based approach (quantification of the activities of catalase, GSTs, and acetylcholinesterase, and also the muscle glycogen content). The here determined LC₅₀-96 h for zinc pyrithione was 2.17 mg/L. ZnPT caused significant increases in the activity of catalase and of cholinesterases. These findings evidence the pro-oxidative effects caused by the metabolism of ZnPT. Despite the absence of clear effects, it is important to stress that the presence of ZnPT in the wild is usually accompanied by other pyrithiones, whose co-existence can contribute to the exertion of considerable toxic effects.

巯氧吡啶锌（ZnPT）是一种具有杀菌，除藻和杀真菌活性的有机金属杀生物剂。考虑到这种生物活性，ZnPT已被用于防污漆，人体治疗剂和化妆品，香波中以治疗头皮屑和皮脂溢。尽管其潜在用途和在水生环境中的潜在存在，但对ZnPT的生态毒理学影响知之甚少。这项工作旨在使用经典方法（LC ₅₀测定）和基于生物标志物的方法（定量）来表征ZnPT对亚洲蛤的生化参数的影响，亚洲蛤是在水依赖性行业中以其生物污染作用而闻名的最具侵入性的双壳类之一。过氧化氢酶，GST和乙酰胆碱酯酶的活性，以及​​肌肉糖原含量）。此处确定的LC巯氧吡啶锌的₅₀ -96 h为2.17 mg / L。ZnPT引起过氧化氢酶和胆碱酯酶活性的显着增加。这些发现证明了由ZnPT的代谢引起的促氧化作用。尽管没有明显的作用，但需要强调的是，野生环境中ZnPT的存在通常还伴随着其他巯氧吡啶酮的存在，它们的共存可有助于发挥相当大的毒性作用。