Peptide 1 with an Aβ42 amyloid nucleating core demonstrates step-wise self-assembly in water. Variation of temperature or solvent composition arrests the self-assembly to give metastable nanoparticles, which undergo self-assembly on gradual increase in temperature and eventually produce kinetically controlled nanofibers and thermodynamically stable twisted helical bundles. Mechanical agitation of the fibers provided access to short seeds with narrow polydispersity index, which by mediation of seeded supramolecular polymerization establishes perfect control over the length of the nanofibers. Such pathway dependence and the length control of the supramolecular peptide nanofibers is exploited to tune the mechanical strength of the resulting hydrogel materials.

中文翻译：

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受淀粉样物质启发的肽两亲分子中由途径驱动的自组装和活性超分子聚合†

具有Aβ42淀粉样蛋白核核心的肽1在水中表现出逐步的自组装。温度或溶剂组成的变化会阻止自组装，从而产生亚稳态的纳米粒子，随着温度的逐渐升高，纳米粒子会进行自组装，最终产生动力学控制的纳米纤维和热力学稳定的扭曲螺旋束。纤维的机械搅动提供了接近具有窄多分散指数的短种子的途径，其通过种子超分子聚合的介导建立了对纳米纤维长度的完美控制。利用这种途径依赖性和超分子肽纳米纤维的长度控制来调节所得水凝胶材料的机械强度。