A new method for rapid late‐stage fluorination using the cation pool technique is presented. Fluorination and no‐carrier‐added radiofluorination of methyl (phenylthio) acetate, methyl 2‐(methylthio) acetate, and methyl 2‐(ethylthio) acetate were performed. The carbocations formed through electrochemical oxidation were stabilized by using a divided electrochemical cell and 2,2,2‐trifluoroethanol (TFE) as the solvent at −20 °C. At the end of electrolysis, either stable‐isotope [¹⁹F]fluoride or no‐carrier‐added radioactive [¹⁸F]fluoride was added to the reaction mixture to form the fluorinated or radiofluorinated product.

中文翻译：

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电化学闪速氟化和放射性氟化

提出了一种使用阳离子池技术快速后期氟化的新方法。进行了乙酸甲酯（苯硫基），乙酸2-（甲硫基）甲酯和乙酸2-（乙硫基）甲酯的氟化和无载体放射性氟化。通过在20°C下使用分开的电化学槽和2,2,2-三氟乙醇（TFE）作为溶剂，可以稳定通过电化学氧化形成的碳正离子。电解结束时，将稳定同位素[ ¹⁹ F]氟化物或未添加载体的放射性[ ¹⁸ F]氟化物添加到反应混合物中，以形成氟化或放射性氟化的产物。