A Bifunctional Aggregation‐Induced Emission Luminogen for Monitoring and Killing of Multidrug‐Resistant Bacteria,Advanced Functional Materials

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A Bifunctional Aggregation‐Induced Emission Luminogen for Monitoring and Killing of Multidrug‐Resistant Bacteria
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2018-08-30 , DOI: 10.1002/adfm.201804632
Ying Li ₁ , Zheng Zhao ₁ , Jiangjiang Zhang ₂ , Ryan T. K. Kwok ₁ , Sheng Xie ₁ , Rongbing Tang ₂ , Yuexiao Jia ₂ , Junchuan Yang ₂ , Le Wang ₂ , Jacky W. Y. Lam ₁ , Wenfu Zheng ₂ , Xingyu Jiang _{2,

3} , Ben Zhong Tang _{1,

4,

5}

Affiliation

Multidrug‐resistant (MDR) bacteria pose serious threats to public health as there is currently a lack of effective and biocompatible drugs to kill MDR bacteria. Here, a bifunctional aggregation‐induced emission luminogen (AIEgen), triphenylethylene‐naphthalimide triazole (TriPE‐NT), is reported, which is capable of both staining and killing Gram‐positive (G+) and Gram‐negative (G−) bacteria. The intrinsic fluorescence generating ability of the TriPE unit enables TriPE‐NT to monitor the drug–bacteria interactions, meanwhile, the NT unit renders TriPE‐NT the antibacterial activity. Furthermore, TriPE‐NT can generate reactive oxygen species (ROS) under light irradiation and drastically enhance its antibacterial efficacy by photodynamic therapy against wild bacteria and clinical isolated MDR bacteria with a very low toxicity to mammalian cells. Moreover, the efficiency of TriPE‐NT staining on bacteria closely correlates with its antibacterial efficacy. As an example of application, TriPE‐NT is utilized in curing Escherichia coli‐ (E. coli), MDR E. coli‐, Staphylococcus epidermidis‐ (S. epidermidis), and MDR S. epidermidis‐ infected wounds on rats with high efficacy and high safety. Thus, TriPE‐NT can be used not only as a powerful antibiotic agent for treating MDR bacteria‐infected diseases but also as a potential fluorescent agent for monitoring the bacterial infections and further exploring the related antibacterial mechanism.

中文翻译：

双功能聚集诱导的发光原用于监测和杀死耐多药细菌

多药耐药（MDR）细菌对公共健康构成了严重威胁，因为目前缺乏有效且生物相容的药物来杀死MDR细菌。此处报道了一种双功能聚集诱导发光致发光剂（AIEgen），三苯基乙烯-萘二甲酰亚胺三唑（TriPE-NT），它能够染色和杀死革兰氏阳性（G +）和革兰氏阴性（G-）细菌。TriPE装置固有的荧光产生能力使TriPE-NT能够监测药物-细菌的相互作用，同时，NT装置使TriPE-NT具有抗菌活性。此外，TriPE‐NT可以在光照射下产生活性氧（ROS），并通过光动力疗法对野生细菌和临床分离的MDR细菌进行光动力疗法，从而大大增强其抗菌功效，而对哺乳动物细胞的毒性则非常低。而且，TriPE-NT染色对细菌的效率与其抗菌功效密切相关。作为应用示例，TriPE-NT用于固化大肠杆菌coli-（大肠杆菌），MDR E. coli-，葡萄球菌epidermidis-（表皮葡萄球菌），和MDR S. epidermidis-对大鼠具有高效力和高安全性感染的伤口。因此，TriPE-NT不仅可以用作治疗MDR细菌感染疾病的有力抗生素，而且还可以用作监测细菌感染并进一步探索相关抗菌机制的潜在荧光剂。

更新日期：2018-08-30

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