Hybrid block copolymers of polyesters/polycarbonates and polypeptides synthesized via one-pot sequential ring-opening polymerization†,Polymer Chemistry

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Hybrid block copolymers of polyesters/polycarbonates and polypeptides synthesized via one-pot sequential ring-opening polymerization†
Polymer Chemistry ( IF 4.1 ) Pub Date : 2018-08-28 00:00:00 , DOI: 10.1039/c8py00835c
Špela Gradišar _{1,

2,

3,

4,

5} , Ema Žagar _{1,

2,

3,

4} , David Pahovnik _{1,

2,

3,

4}

Affiliation

An efficient approach toward one-pot sequential ring-opening polymerization (ROP) of cyclic esters/carbonates and N-carboxyanhydride (NCA) monomers, differing in reactivity and type of propagating group, is presented. In the first step, a polyester/polycarbonate is synthesized using methanesulfonic acid as a catalyst. After the completion of polymerization NCA is added to the reaction mixture. Methanesulfonic acid successfully catalyzes the initiation step of ROP of NCA and simultaneously prevents the chain propagation by protonation of the formed amine groups. After the completion of NCA initiation, the propagation is started by addition of N-ethyldiisopropylamine as a base to prepare the hybrid block copolymers of polyester/polycarbonate and polypeptide in a one-pot manner.

中文翻译：

通过一锅顺序开环聚合合成的聚酯/聚碳酸酯和多肽的杂化嵌段共聚物†

提出了一种有效的方法来实现环酯/碳酸酯和N-羧基酸酐（NCA）单体的一锅顺序开环聚合（ROP），反应活性和繁殖基团的类型不同。第一步，使用甲磺酸作为催化剂合成聚酯/聚碳酸酯。聚合完成后，将NCA加入反应混合物中。甲磺酸成功地催化了NCA的ROP的引发步骤，并同时通过形成的胺基的质子化防止链增长。在NCA引发完成之后，通过添加N-乙基二异丙胺为碱开始繁殖，以一锅法制备聚酯/聚碳酸酯和多肽的杂化嵌段共聚物。

更新日期：2018-08-28

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