Non‐Directed Cross‐Dehydrogenative (Hetero)arylation of Allylic C(sp3)−H bonds enabled by C−H Activation,Angewandte Chemie International Edition

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Non‐Directed Cross‐Dehydrogenative (Hetero)arylation of Allylic C(sp3)−H bonds enabled by C−H Activation
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2018-10-12 , DOI: 10.1002/anie.201807047
Andreas Lerchen ₁ , Tobias Knecht ₁ , Maximilian Koy ₁ , Johannes B. Ernst ₁ , Klaus Bergander ₁ , Constantin G. Daniliuc ₁ , Frank Glorius ₁

Affiliation

Herein, we report the selective, non‐directed and cross‐dehydrogenative coupling of allylic C(sp³)−H bonds with C(sp²)−H bonds of (hetero)arenes. The methodology employs olefins and (hetero)arenes which are abundantly available chemical feedstocks, and could be applied in late‐stage functionalization reactions of pharmaceuticals. Furthermore, the system exclusively delivers the allylic C−C coupling products highlighting the preservation of the olefin substitution pattern for further derivatization.

中文翻译：

通过CH活化实现的烯丙基C（sp3）-H键的非定向交叉脱氢（杂）芳基化

在这里，我们报告了烯丙基C（sp ³）-H键与（杂）芳烃的C（sp ²）-H键的选择性，非定向和交叉脱氢偶联。该方法采用了烯烃和（杂）芳烃，它们是大量可利用的化学原料，可用于药物的后期功能化反应。此外，该系统专门提供烯丙基C-C偶联产物，突出显示了烯烃取代模式的保留，以便进一步衍生化。

更新日期：2018-10-12

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