Importance of Theranostics in Rare Brain-Eating Amoebae Infections.,ACS Chemical Neuroscience

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Importance of Theranostics in Rare Brain-Eating Amoebae Infections.
ACS Chemical Neuroscience ( IF 4.1 ) Pub Date : 2018-09-10 , DOI: 10.1021/acschemneuro.8b00321
Ayaz Anwar ₁ , Ruqaiyyah Siddiqui ₁ , Naveed Ahmed Khan ₁

Affiliation

Pathogenic free-living amoebae including Acanthamoeba spp., Balamuthia mandrillaris, and Naegleria fowleri cause infections of the central nervous system (CNS), which almost always prove fatal. The mortality rate is high with the CNS infections caused by these microbes despite modern developments in healthcare and antimicrobial chemotherapy. The low awareness, delayed diagnosis, and lack of effective drugs are major hurdles to overcome these challenges. Nanomaterials have emerged as vital tools for concurrent diagnosis and therapy, which are commonly referred to as theranostics. Nanomaterials offer highly sensitive diagnostic systems and viable therapeutic effects as a single modality. There has been good progress to develop nanomaterials based efficient theranostic systems against numerous kinds of tumors, but this field is yet immature in the context of infectious diseases, particularly parasitic infections. Herein, we describe the potential value of theranostic applications of nanomaterials against brain infections due to pathogenic amoebae.

中文翻译：

Theranostics在难吃的大脑食性变形虫感染中的重要性。

致病性的自由活动变形虫，包括棘形棘阿米巴菌，曼陀罗Balamuthia mandrillaris和福氏Naegleria fowleri，都导致中枢神经系统（CNS）感染，几乎总是致命。尽管医疗保健和抗菌化学疗法有了新的发展，但这些微生物引起的中枢神经系统感染的死亡率仍然很高。认识不足，诊断延迟和缺乏有效药物是克服这些挑战的主要障碍。纳米材料已经成为并发诊断和治疗的重要工具，通常被称为诊断学。纳米材料提供了高度灵敏的诊断系统和可行的治疗效果。在开发基于纳米材料的有效的治疗方法系统方面，已经取得了良好的进展，该系统可治疗多种肿瘤，但是在传染病尤其是寄生虫感染方面，这个领域还不成熟。在本文中，我们描述了纳米材料在肿瘤治疗中的潜在应用价值，可用于治疗因致病性变形虫引起的脑部感染。

更新日期：2018-08-27

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