Allergic rhinitis (AR) is a global health problem because of its steadily increasing incidence and prevalence that currently affects about 30% of people worldwide. β-eudesmol has various beneficial effects, including anti-cancer and anti-allergic activities. However, the effects of β-eudesmol on AR have not yet been clarified; thus, we investigated the effects of β-eudesmol in an ovalbumin-induced AR animal model using enzyme-linked immunosorbent assay, histamine assay, Western blotting, and hematoxylin and eosin staining methods. β-eudesmol reduced the nasal rubs score and levels of histamine and immunoglobulin E in serum of AR mouse. In addition, the levels of thymic stromal lymphopoietin, interleukin-1β, tumor necrosis factor-α, and macrophage inflammatory protein-2 were down-regulated and infiltration of eosinophils and the level of intercellular adhesion molecule-1 were inhibited by β-eudesmol administration. β-eudesmol administration also reduced active caspase-1 and nuclear factor-κB DNA binding activity in nasal mucosa tissues of AR mice. Taken together, these results indicate that β-eudesmol would be effective for the treatment of allergic and inflammatory diseases, such as AR.

变应性鼻炎（AR）是一个全球性的健康问题，因为它的发病率和患病率稳步上升，目前影响着全世界约30％的人。β-大麦醇具有多种有益作用，包括抗癌和抗过敏活性。然而，β-芥子油苷对AR的作用尚不清楚。因此，我们使用酶联免疫吸附测定，组胺测定，Western印迹以及苏木精和曙红染色法研究了卵磷脂在AR引起的卵白蛋白诱导的动物模型中的作用。β-迷迭香酚可降低AR小鼠的鼻擦分数以及组胺和免疫球蛋白E的水平。此外，胸腺基质淋巴细胞生成素，白介素-1β，肿瘤坏死因子-α，β-eudesmol给药可抑制人巨噬细胞和巨噬细胞炎性蛋白2的表达，并抑制嗜酸性粒细胞的浸润和细胞间黏附分子1的表达。给予β-eudesmol也降低了AR小鼠鼻黏膜组织中的活性caspase-1和核因子-κBDNA结合活性。综上所述，这些结果表明β-eudesmol对治疗变应性和炎性疾病如AR将是有效的。