Polyphenols are secondary metabolites found in all vascular plants and constitute a large group of at least 10,000 unique compounds. Particular attention is currently being paid to polyphenols attributed to their beneficial effects in the protection and prevention of several diseases. While their use in food, pharmaceutical and cosmetic industries is largely documented, several environmental conditions (e.g. light, temperature or oxygen) may affect the physicochemical stability of polyphenols, compromising their bioactivity in vivo. To overcome these limitations, the loading of polyphenols into nanoparticles has been proposed aiming at both increasing their bioavailability and reducing eventual side effects. Lipid nanoparticles offer several advantages, namely their biodegradability and low toxicity, with the additional capacity to modify the release profile of loaded drugs.

This paper is a review of the recent advances of lipid nanocarriers commonly used for the encapsulation of polyphenols, highlighting their added value to increase bioavailability and bioactivity of this group of compounds as well as their application in several diseases.

多酚是在所有维管植物中发现的次生代谢产物，构成至少10,000种独特化合物的一大组。由于多酚在保护和预防几种疾病中的有益作用，目前正在特别注意。尽管它们在食品，制药和化妆品行业中的使用已有大量文献记载，但几种环境条件（例如光，温度或氧气）可能会影响多酚的理化稳定性，从而损害其在体内的生物活性。。为了克服这些限制，已经提出了将多酚装载到纳米颗粒中的目的在于增加其生物利用度并减少最终的副作用。脂质纳米颗粒具有几个优点，即它们的生物可降解性和低毒性，并具有修饰载药释放特性的额外能力。

本文综述了常用于封装多酚的脂质纳米载体的最新进展，强调了其增加的价值以增加这类化合物的生物利用度和生物活性，以及​​它们在几种疾病中的应用。