当前位置: X-MOL 学术Bioorg. Med. Chem. Lett. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Synthesis of cationic glucosamino nucleic acids for stabilizing oligonucleotides
Bioorganic & Medicinal Chemistry Letters ( IF 2.7 ) Pub Date : 2018-08-25 , DOI: 10.1016/j.bmcl.2018.08.024
Yoshiaki Kitamura , Shuichi Moribe , Yukio Kitade

Glucosamino nucleic acids (GANAs) bearing a β-N-glycoside bond between carbon 1 of the glucosamine and the nucleobase nitrogen were synthesized and incorporated into oligonucleotides (4′,6′-GANA and 3′,6′-GANA). The thermal stability of oligonucleotide duplexes containing the GANA zwitterionic nucleotides was also investigated.



中文翻译:

用于稳定寡核苷酸的阳离子葡糖氨基核酸的合成

合成了在葡糖胺的碳1和核碱基氮之间带有β- N-糖苷键的葡糖氨基核酸(GANA),并将其掺入寡核苷酸(4',6'-GANA和3',6'-GANA)中。还研究了含有GANA两性离子核苷酸的寡核苷酸双链体的热稳定性。

更新日期:2018-08-25
down
wechat
bug