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Recent progresses in small-molecule enzymatic fluorescent probes for cancer imaging
Chemical Society Reviews ( IF 40.4 ) Pub Date : 2018-08-24 00:00:00 , DOI: 10.1039/c7cs00862g Hong-Wen Liu 1, 2, 3, 4, 5 , Lanlan Chen 1, 2, 3, 4, 5 , Chengyan Xu 1, 2, 3, 4, 5 , Zhe Li 1, 2, 3, 4, 5 , Haiyang Zhang 1, 2, 3, 4, 5 , Xiao-Bing Zhang 1, 2, 3, 4, 5 , Weihong Tan 1, 2, 3, 4, 5
Chemical Society Reviews ( IF 40.4 ) Pub Date : 2018-08-24 00:00:00 , DOI: 10.1039/c7cs00862g Hong-Wen Liu 1, 2, 3, 4, 5 , Lanlan Chen 1, 2, 3, 4, 5 , Chengyan Xu 1, 2, 3, 4, 5 , Zhe Li 1, 2, 3, 4, 5 , Haiyang Zhang 1, 2, 3, 4, 5 , Xiao-Bing Zhang 1, 2, 3, 4, 5 , Weihong Tan 1, 2, 3, 4, 5
Affiliation
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Abnormal enzymatic activities are directly related to the development of cancers. Identifying the location and expression levels of these enzymes in live cancer cells have considerable importance in early-stage cancer diagnoses and monitoring the efficacy of therapies. Small-molecule fluorescent probes have become a powerful tool for the detection and imaging of enzymatic activities in biological systems by virtue of their higher sensitivity, nondestructive fast analysis, and real-time detection abilities. Moreover, due to their structural tailorability, numerous small-molecule enzymatic fluorescent probes have been developed to meet various demands involving real-time tracking and visualizing different enzymes in live cancer cells or in vivo. In this review, we provide an overview of recent advances in small-molecule enzymatic fluorescent probes mainly during the past decade, including the design strategies and applications for various enzymes in live cancer cells. We also highlight the challenges and opportunities in this rapidly developing field of small-molecule fluorescent probes for interventional surgical imaging, as well as cancer diagnosis and therapy.
中文翻译：
用于癌症成像的小分子酶促荧光探针的最新进展
异常的酶活性与癌症的发展直接相关。鉴定这些酶在活癌细胞中的位置和表达水平在早期癌症诊断和监测治疗效果中具有相当重要的意义。小分子荧光探针具有较高的灵敏度，无损快速分析和实时检测功能，已成为检测和成像生物系统中酶活性的有力工具。此外，由于其结构的适应性，已开发出许多小分子酶促荧光探针来满足各种需求，包括实时跟踪和可视化活癌细胞或体内的不同酶。。在这篇综述中，我们概述了小分子酶促荧光探针的最新进展，主要是在过去十年中，包括活癌细胞中各种酶的设计策略和应用。我们还重点介绍了在小分子荧光探针这一快速发展的领域中的挑战和机遇，这些小分子荧光探针用于外科手术成像以及癌症诊断和治疗。
更新日期：2018-08-24
中文翻译：
用于癌症成像的小分子酶促荧光探针的最新进展
异常的酶活性与癌症的发展直接相关。鉴定这些酶在活癌细胞中的位置和表达水平在早期癌症诊断和监测治疗效果中具有相当重要的意义。小分子荧光探针具有较高的灵敏度，无损快速分析和实时检测功能，已成为检测和成像生物系统中酶活性的有力工具。此外，由于其结构的适应性，已开发出许多小分子酶促荧光探针来满足各种需求，包括实时跟踪和可视化活癌细胞或体内的不同酶。。在这篇综述中，我们概述了小分子酶促荧光探针的最新进展，主要是在过去十年中，包括活癌细胞中各种酶的设计策略和应用。我们还重点介绍了在小分子荧光探针这一快速发展的领域中的挑战和机遇，这些小分子荧光探针用于外科手术成像以及癌症诊断和治疗。
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