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The determining role of nanoscale mechanical twinning on cellular functions of nanostructured materials
Journal of the Mechanical Behavior of Biomedical Materials ( IF 3.3 ) Pub Date : 2018-08-24 , DOI: 10.1016/j.jmbbm.2018.08.033
K.C. Nune , I. Montes , V.S.Y. Injeti , M.C. Somani , R.D.K. Misra

Considering that micromotions generated at the bone-implant interface under physiological loading introduce mechanical strain on the tissue and surface of the implant and that strain can be introduced during processing of the biomedical device, we elucidate here the interplay between mechanically-induced nanoscale twinning in austenitic stainless steel on osteoblast functions. Mechanically-induced nanoscale twinning significantly impacted cell attachment, cell-substrate interactions, proliferation, and subsequent synthesis of prominent proteins (fibronectin, actin, and vinculin). Twinning was beneficial in favorably modulating cellular activity and contributed to small differences in hydrophilicity and nanoscale roughness in relation to the untwinned surface.



中文翻译:

纳米级机械孪晶对纳米结构材料的细胞功能的决定性作用

考虑到在生理负荷下在骨-植入物界面处产生的微运动在植入物的组织和表面上引入了机械应变,并且该应变可以在生物医学装置的加工过程中引入,因此我们在此阐明奥氏体中机械诱导的纳米级孪晶之间的相互作用。不锈钢对成骨细胞的功能。机械诱导的纳米级孪晶显着影响细胞附着,细胞-底物相互作用,增殖以及随后的突出蛋白(纤连蛋白,肌动蛋白和纽蛋白)的合成。孪晶对有利地调节细胞活性是有益的,并且相对于未缠绕的表面,有助于亲水性和纳米级粗糙度的微小差异。

更新日期:2018-08-24
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