In the present work, a new type of porous Ti-based alloy scaffold with high porosity (about 75%) and interconnected pores in the range of 300–1000 µm was fabricated by polymeric foam replication method with TiNbZr powders. This porous scaffold, which is consisted with major β phase Ti and minor α Ti phase, exhibits a compressive strength of 14.9 MPa and an elastic modulus of 0.21 GPa, resembling the mechanical properties of nature human cancellous bone (σ = 10–50 MPa, E = 0.01–3.0 GPa). To improve its osteogenic potential, a bioactive nanostructural titanate network coating was applied to the scaffold surface using hydrothermal treatment. The bone-like apatite inducing ability of the treated scaffold was systemically assessed using SBF immersion during 3–28 days. The nanostructural titanate network coated on porous TiNbZr scaffold is favorable for apatite nucleation and subsequent growth due to the hydrolysis of titanate. The results suggest that highly porous TiNbZr scaffolds with an appropriate bioactive coating, which was fabricated in this study, could be potentially used for bone tissue engineering application.

在目前的工作中，采用TiNbZr粉末通过聚合物泡沫复制法制备了一种新型的高孔隙率（约75％），互连孔隙在300-1000 µm范围内的多孔Ti基合金支架。这种多孔支架由主要的β相Ti和次要的αTi相组成，具有14.9 MPa的抗压强度和0.21 GPa的弹性模量，类似于人类松质骨的力学性能（σ= 10–50 MPa， E = 0.01–3.0 GPa）。为了提高其成骨潜能，使用水热处理将生物活性的纳米结构钛酸酯网络涂层施加到支架表面。在3–28天内使用SBF浸泡系统评估了治疗后支架的骨样磷灰石诱导能力。涂覆在多孔TiNbZr支架上的纳米结构钛酸酯网络由于钛酸酯的水解而有利于磷灰石成核和随后的生长。结果表明，在本研究中制造的具有适当生物活性涂层的高孔隙度TiNbZr支架可潜在地用于骨组织工程应用。