Handheld adaptive optics scanning laser ophthalmoscope,Optica

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Handheld adaptive optics scanning laser ophthalmoscope
Optica ( IF 8.4 ) Pub Date : 2018-08-23 , DOI: 10.1364/optica.5.001027
Theodore DuBose ₁ , Derek Nankivil ₁ , Francesco LaRocca ₁ , Gar Waterman ₁ , Kristen Hagan ₁ , James Polans ₁ , Brenton Keller ₁ , Du Tran-Viet ₂ , Lejla Vajzovic ₂ , Anthony N Kuo _{1,

2} , Cynthia A Toth _{1,

2} , Joseph A Izatt _{1,

2} , Sina Farsiu _{1,

2}

Affiliation

Adaptive optics scanning laser ophthalmoscopy (AOSLO) has enabled in vivo visualization and enhanced understanding of retinal structure and function. Current generation AOSLOs have a large footprint and are mainly limited to imaging cooperative adult subjects. To extend the application of AOSLO to new patient populations, we have designed, to the best of our knowledge, the first portable handheld AOSLO (HAOSLO) system. By incorporating a novel computational wavefront sensorless AO algorithm and custom optics, we have miniaturized our HAOSLO to weigh less than 200 g. HAOSLO imaged the cones closest to the fovea with a handheld probe in adults and captured, to the best of our knowledge, the first AO-enhanced image of cones in infants.

中文翻译：

手持式自适应光学扫描激光检眼镜

自适应光学扫描激光检眼镜 (AOSLO) 实现了体内可视化并增强了对视网膜结构和功能的理解。当前一代 AOSLO 占地面积较大，主要限于对合作成人受试者进行成像。为了将 AOSLO 的应用扩展到新的患者群体，据我们所知，我们设计了第一个便携式手持式 AOSLO (HAOSLO) 系统。通过结合新型计算波前无传感器 AO 算法和定制光学器件，我们将 HAOSLO 小型化，重量小于 200 克。HAOSLO 使用手持式探头对成人中最接近中央凹的视锥细胞进行成像，并据我们所知，捕获了婴儿中第一个 AO 增强的视锥细胞图像。

更新日期：2018-09-21

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