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Ion-Exchange Microemulsions for Eliminating Dilute Interferences in Potentiometric Determinations
Electroanalysis ( IF 2.7 ) Pub Date : 2018-08-22 , DOI: 10.1002/elan.201800366
Sutasinee Apichai 1, 2, 3 , Lu Wang 1 , Nadezda Pankratova 1 , Kate Grudpan 2, 3 , Eric Bakker 1
Affiliation  

We report here for the first time on the use of functional microemulsions in potentiometric assays to remove dilute interferences from solution when measuring high concentrations of analyte. The microemulsions are similarly formulated to the ion-selective membrane used in the measurement and act as sacrificial material. They are here stabilized by the triblock copolymer pluronic F- 127 and contain the chloride salt of the tridodecylmethylammonium cation, which also serves as anion-exchanger in the membrane electrode. Both membrane and microemulsion are preconditioned with chloride. If an anionic interference is present at moderate concentration, the rapid equilibration with the functionalized microemulsion results in a quantitative removal. The principle is explored with salicylate as common interference in the detection of chloride in physiological samples. The data agree well to an equilibrium ion-exchange model for the microemulsion. Salicylate levels up to millimolar can be effectively removed. Unfortunately, quaternary ammonium salt from the microemulsion is found to contaminate the ionselective membrane phase. Indeed, a cation-exchanging valinomycin membrane in contact with concentrated anion-exchanging microemulsions shows a large potential increase. This indicates that the membrane changes from cation to anion permselectivity. This contamination of the membrane by the microemulsion phase must be overcome for a practical application of the approach.

中文翻译:

用于消除电位测定中的稀释干扰的离子交换微乳液

我们在此首次报告在电位测定中使用功能性微乳液在测量高浓度分析物时去除溶液中的稀释干扰物。微乳液与测量中使用的离子选择性膜类似地配制并充当牺牲材料。它们在这里由三嵌段共聚物普朗尼克 F-127 稳定并含有十三烷基甲基铵阳离子的氯化物盐,它也用作膜电极中的阴离子交换剂。膜和微乳液均用氯化物预处理。如果阴离子干扰以中等浓度存在,则与功能化微乳液的快速平衡会导致定量去除。将水杨酸盐作为检测生理样品中氯化物的常见干扰物来探索该原理。数据与微乳液的平衡离子交换模型非常吻合。可以有效去除高达毫摩尔的水杨酸盐水平。不幸的是,发现来自微乳液的季铵盐会污染离子选择性膜相。事实上,与浓缩阴离子交换微乳液接触的阳离子交换缬氨霉素膜显示出很大的电位增加。这表明膜从阳离子渗透选择性变为阴离子渗透选择性。对于该方法的实际应用,必须克服微乳液相对膜的污染。可以有效去除高达毫摩尔的水杨酸盐水平。不幸的是,发现来自微乳液的季铵盐会污染离子选择性膜相。事实上,与浓缩阴离子交换微乳液接触的阳离子交换缬氨霉素膜显示出很大的电位增加。这表明膜从阳离子渗透选择性变为阴离子渗透选择性。对于该方法的实际应用,必须克服微乳液相对膜的污染。可以有效去除高达毫摩尔的水杨酸盐水平。不幸的是,发现来自微乳液的季铵盐会污染离子选择性膜相。事实上,与浓缩阴离子交换微乳液接触的阳离子交换缬氨霉素膜显示出很大的电位增加。这表明膜从阳离子渗透选择性变为阴离子渗透选择性。对于该方法的实际应用,必须克服微乳液相对膜的污染。这表明膜从阳离子渗透选择性变为阴离子渗透选择性。对于该方法的实际应用,必须克服微乳液相对膜的污染。这表明膜从阳离子渗透选择性变为阴离子渗透选择性。对于该方法的实际应用,必须克服微乳液相对膜的污染。
更新日期:2018-08-22
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